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. 2014 May 7;192(12):5821–5829. doi: 10.4049/jimmunol.1400404

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FIGURE 5. — IL-2/αCD40 activates caspases on Tregs and MDSCs in the tumor and spleen. Renca or 4T1 tumor-bearing mice were treated with VC or IL-2/αCD40. On day 15, the primary tumors and spleens were harvested. Activated caspases were analyzed on day 15 using the cell-permeable CaspGLOW active staining kit and flow cytometry. (A and C) Results from tumor-associated leukocytes and splenocytes from Renca tumor-bearing mice, respectively. (B and D) Results from tumor-associated leukocytes and splenocytes from 4T1-tumor bearing mice, respectively. Statistics were computed in comparison with the corresponding VC (*p < 0.05; ns, not significant). Data are derived from five mice per treatment group in two separate experiments.