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. Author manuscript; available in PMC: 2015 Jun 15.
Published in final edited form as: J Immunol. 2014 Apr 30;192(12):5839–5851. doi: 10.4049/jimmunol.1302729

Figure 5. Enhanced lung injury and CD8+ T-cell responses in TNFR1−/− mice following influenza infection.

Figure 5

WT, TNFR1−/−, and TNFR2−/− mice were infected with a sub-lethal dose of influenza virus. (A) Weight loss was monitored daily and the percent baseline weight change for day 8 post-infection was calculated. (B) ELISA was used to determine the levels of albumin in the BALF 8 days post-infection. (C) The total number of viable cells recovered from BAL day 8 post-infection. Flow cytometry was used to analyze the total number of (D) CD8+, (E) NP366–374-specific CD8+, and (F) CD107a+CD8+ T cells. Data represent mean ± standard deviation. Each group consists of 4–6 mice. Data are representative of at least two independent experiments. *P<0.05, **P<0.01, ***P<0.005.