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. Author manuscript; available in PMC: 2015 Jun 15.
Published in final edited form as: J Immunol. 2014 May 14;192(12):6053–6061. doi: 10.4049/jimmunol.1301481

Figure 2. IL-36 induces myeloid cell infiltration of skin concomitant with chemokine and growth factor induction.

Figure 2

5μg rmIL-36α or BSA was injected intradermally into CD1 mice every other day for 10 days. Back skin was harvested, snap frozen, processed for RNA and histochemistry. IL-36α treatment lead to acanthosis and an increase in eosinophilic dermal collagen (a) and striking infiltration of granulocytes (CD11b, b), macrophages (F4/80, c), dendritic cells (CD11c, d) CD4+ cells (e) but not CD8+ cells (f). These changes were accompanied by increases in chemokines (g) and cytokines/growth factors (h). Mean ± SEM (n=4 mice). Statistical significance indicated by * p<0.05 (2-tailed t-test). Scale bar = 100μm.