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. Author manuscript; available in PMC: 2014 Jun 9.
Published in final edited form as: J Nephrol. 2012 May-Jun;25(3):269–275. doi: 10.5301/jn.5000174

Fig. 1.

Fig. 1

Model for the effects of calcineurin inhibitors on vascular tone, sympathetic nervous system and kidney sodium retention. Question marks refer to interactions that have been shown in other studies, but not in the context of CNIs (10, 11). Ang II = angiotensin II; NCC = sodium chloride cotransporter; ROS = reactive oxygen species; SNS = sympathetic nervous system; SPAK = Ste20-related kinase; WNK = with no K (K = lysine).