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. Author manuscript; available in PMC: 2014 Oct 15.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Aug 14;23(20):5689–5693. doi: 10.1016/j.bmcl.2013.08.014

Figure 3.

Figure 3

CD titration profile of TAR RNA with DPA 123. The ligand was added serially to the RNA solution in small increments as displayed on the graph. After each successive addition, the nucleic acid ligand-complex was stirred and equilibrated for five minutes before the spectrum was recorded. Each spectrum shown in the figure is an average of three scans. The experiments were performed in cacodylate buffer containing 10 mM sodium cacodylate, 0.5 mM EDTA, 100 mM KCl at pH 6.8. (T = 20 °C). The boxed regions have been expanded for clarity.