Table 1.

Peripheral quantitative computed tomography assessed bone density and cortical geometry of the femur for paired samples tested at two different loading rates (20 mm/min=right; 2 mm/min = left).

	20 mm/min testing rate		2 mm/min testing rate		Drug	Rate	Drug × Rate
	Vehicle	Zoledronate	Vehicle	Zoledronate
Distal femur total vBMD, mg/cm3	660 ± 17	732 ± 14	-	-	0.001	-	-
Mid-diaphysis BMC, mg/mm	16.3 ± 0.4	16.3 ± 0.5	16.6 ± 0.4	16.6 ± 0.5	NS	NS	NS
Mid-diaphysis vBMD, mg/cm3	1487 ± 4	1491 ± 4	1490 ± 5	1494 ± 4.2	NS	NS	NS
Cortical bone area, mm2	11.0 ± 0.3	11.0 ± 0.3	11.2 ± 0.3	11.1 ± 0.3	NS	NS	NS
Polar cross-sectional moment of inertia, mm4	39.0 ± 2.3	39.2 ± 2.7	39.5 ± 2.2	39.1 ± 2.4	NS	NS	NS
A-P diameter, mm	4.0 ± 0.07	4.0 ± 0.07	4.0 ± 0.06	4.0 ± 0.07	NS	NS	NS

Data presented as mean ± standard error.

Significant p-values included for two-way ANOVA results. NS, non-significant.

vBMD, volumetric bone mineral density; BMD, bone mineral content; A-P, anterior-posterior.