Table 2.

Structural and material biomechanical properties of the femoral diaphysis assessed by three-point bending at two different loading rates (20 mm/min=right; 2 mm/min = left).

	20 mm/min testing rate		2 mm/min testing rate		Drug	Rate	Drug × Rate
	Vehicle	Zoledronate	Vehicle	Zoledronate
Ultimate Load, N	297 ± 8	393 ± 12	260 ± 8	263 ± 10	NS	0.001	NS
Stiffness, N/mm	573 ± 16	567 ± 23	518 ± 10	538 ± 14	NS	0.014	NS
Energy to failure, Nmm	214 ± 13	232 ± 14	232 ± 13	197 ± 12 *	NS	NS	0.05
Post-ultimate load energy to failure, Nmm	40.3 ± 9.9	58.7 ± 15	91.6 ± 8.6	53.8 ± 12 *	NS	0.041	0.019
Post-yield energy to failure, Nmm	170 ± 13	178 ± 14	203 ± 14	170 ± 11	NS	NS	NS
Ultimate Stress, MPa	74 ± 3	74 ± 2	64 ± 1	64 ± 1	NS	0.001	NS
Modulus, MPa	2154 ± 80	2129 ± 90	1933 ± 82	2030 ± 96	NS	0.067	NS
Toughness, MJ/m3	3.6 ± 0.2	3.8 ± 0.3	3.8 ± 0.2	3.2 ± 0.2	NS	NS	0.07
Post-ultimate stress toughness, MJ/m3	0.69 ± 0.19	1.0 ± 0.3	1.49 ± 0.13	0.9 ± 0.2 *	NS	0.078	0.033
Post-yield toughness, MJ/m3	2.83 ± 0.21	2.91 ± 0.25	3.29 ± 0.18	2.75 ± 0.21	NS	NS	NS

Data presented as mean ± standard error.

Significant p-values included for two-way ANOVA results. NS, non-significant;

^*p < 0.05 versus vehicle within test rate as determined by least squares means post-hoc test.