Table 3.
Comparison of Baseline Characteristics of Cancer-Related Fatigue Cases and Non-Cases at 6 and 42 Months Post-Treatment Assessments
| 6 Month Post-Tx | 42 Month Post-Tx | |||||
|---|---|---|---|---|---|---|
| Variable | CRF Cases n526 |
CRF Noncases n5256 |
P | CRF Cases n529 |
CRF Noncases n5193 |
P |
| Age,a y | 54.8 [8.1] {43–70} | 55.1 [9.9] {29–82} | .863 | 52.1 [8.0] {38–67} | 54.3 [9.5] {29–78} | .236 |
| BMIa | 28.0 [6.7] {18–46} | 27.2 [6.1] {13–63} | .536 | 29.8 [7.0] {20–46} | 26.8 [5.2] {17–43} | .008 |
| No. of physical comorbiditiesa | 0.7 [0.7] {0–2} | 0.4 [0.8] {0–4} | .154 | 0.7 [0.8] {0–3} | 0.4 [0.7] {0–3} | .053 |
| FCS-fatigue catastrophizinga | 16.5 [4.1] {11–25} | 14.8 [5.1] {10–35} | .091 | 18.0 [6.6] {10–35} | 14.4 [4.6] {10–32} | .000 |
| IMQ accommodating to illnessa | 47.6 [9.8] {36–77} | 49.0 [9.9] {26–78} | .500 | 44.7 [9.1] {29–62} | 48.7 [9.4] {23–77} | .034 |
| IMQ focusing on illnessa | 26.6 [6.6] {19–44} | 25.5 [7.4] {12–52} | .455 | 28.4 [7.6] {19–52} | 25.2 [7.0] {12–42} | .021 |
| Disease stage | .567 | .585 | ||||
| 0 | 4 (16%) | 27 (11%) | 3 (10%) | 20 (10%) | ||
| I | 11 (42%) | 134 (52%) | 13 (45%) | 105 (55%) | ||
| II | 11 (42%) | 95 (37%) | 13 (45%) | 68 (35%) | ||
| Mastectomyb | 6 (23%) | 30 (12% | .119 | 7 (24%) | 22 (11%) | .074 |
| Adjuvant treatment | .154 | .216 | ||||
| RT only | 10 (38%) | 136 (53%) | 11 (38%) | 97 (50%) | ||
| CT only or CT1RT | 16 (62%) | 120 (47%) | 18 (62%) | 96 (50%) | ||
| ≤High school graduate | 8 (31%) | 61 (24%) | .474 | 7 (24%) | 42 (22%) | .811 |
| Obesec | 9 (35%) | 74 (29%) | .653 | 13 (45%) | 50 (26%) | .048 |
| Postmenopausal | 15 (63%) | 159 (63%) | .999 | 17 (59%) | 118 (62%) | .838 |
| UK study site | 8 (31%) | 99 (39%) | .527 | 16 (55%) | 13 (45%) | .021 |
| Married/Partnered | 19 (73%) | 186 (73%) | .999 | 20 (69%) | 147 (76%) | .489 |
| Minority | 4 (15%) | 21 (8%) | .266 | 4 (14%) | 18 (9%) | .502 |
| History of major depression | 8 (31%) | 41 (16%) | .098 | 9 (31%) | 29 (15%) | .060 |
Tx indicates treatment; CRF, cancer-related fatigue; BMI, body mass index; FCS, Fatigue Catastrophizing Scale; IMQ, Illness Management Questionnaire; RT, radiotherapy; CT, chemotherapy; UK, United Kingdom.
a
Mean [SD, standard deviation from the mean] {Range}
b
Includes bilateral mastectomy or lumpectomy plus mastectomy
c
Defined as ≥30 kg/m2