Table 5.

Comparison of CRF Cases, Noncases, and Healthy Controls at the 42-Month Post-Treatment Assessment

Variable	CRF Cases n529	CRF Non-Cases n5193	Healthy Controls n5194	Pa	Group Differencesb	ESc
	Mean (SD) [Range]	Mean (SD) [Range]	Mean (SD) [Range]
SF-36 indicesd
General health	47.9 (19.1) [10–82]	74.3 (20.1) [15–100]	74.7 (19.8) [5–100]	≤.001	C vs NC, HC	1.21
Physical functioning	51.6 (23.1) [15–95]	81.0 (21.1) [0–100]	81.7 (22.1) [5–100]	≤.001	C vs NC, HC	1.25
Social functioning	62.9 (21.0) [0–100]	89.4 (17.7) [12–100]	89.3 (20.2) [25–100]	≤.001	C vs NC, HC	1.31
Mental health	63.3 (20.2) [24–96]	83.4 (13.5) [12–100]	80.4 (16.4) [12–100]	≤.001	C vs NC, HC	1.26
Vitality	27.8 (21.1) [0–75]	62.7 (20.0) [10–100]	61.0 (21.0) [0–100]	≤.001	C vs NC, HC	1.50
Role: physical function	35.3 (35.0) [0–100]	77.9 (33.7) [0–100]	86.2 (27.5) [0–100]	≤.001	C vs NC vs HC	1.16
Role: emotional function	46.0 (42.2) [0–100]	89.2 (25.3) [0–100]	85.6 (30.5) [0–100]	≤.001	C vs NC, HC	1.37
Physical health composite	35.8 (9.1) [21–55]	47.8 (9.8) [14–66]	49.2 (9.1) [20–63]	≤.001	C vs NC, HC	1.14
Mental health composite	42.2 (12.6) [18–67]	54.6 (7.9) [24–69]	52.9 (9.3) [16–66]	≤.001	C vs NC, HC	1.30
FSI indicese
Least fatigue	4.0 (2.4) [0–9]	1.1 (1.6) [0–8]	1.3 (1.8) [0–9]	≤.001	C vs NC, HC	1.49
Most fatigue	7.5 (1.8) [4–10]	3.4 (2.7) [0–10]	3.6 (2.8) [0–10]	≤.001	C vs NC, HC	1.38
Average fatigue	5.9 (1.8) [2–9]	2.1 (1.9) [0–8]	2.3 (2.1) [0–9]	≤.001	C vs NC, HC	1.67
Fatigue interference	31.5 (15.4) [4–65]	7.0 (9.8) [0–60]	8.4 (12.6) [0–62]	≤.001	C vs NC, HC	1.83
No. of days fatigued	6.0 (1.7) [2–7]	2.6 (2.5) [0–7]	2.3 (2.1) [0–7]	≤.001	C vs NC, HC	1.31
Portion day fatigued	6.2 (2.8) [1–10]	2.3 (2.2) [0–10]	2.3 (2.3) [0–10]	≤.001	C vs NC, HC	1.49
Other indicese
POMS-fatigue	15.8 (6.6) [3–28]	4.6 (4.6) [0–23]	4.6 (5.5) [0–28]	≤.001	C vs NC, HC	1.84
CES-D	19.4 (8.9) [4–40]	6.8 (6.4) [0–45]	8.5 (8.9) [0–42]	≤.001	C vs NC, HC	1.31

CRF indicates cancer-related fatigue; ES, effect size; SD, standard deviation from the mean; C, cases; NC, noncases; HC, healthy controls; SF-36, The Medical Outcome Study Health Survey; FSI, Fatigue Symptom Inventory; POMS, Profile of Mood States; CES-D, Center for Epidemiologic Studies Depression Scale.

^aP-value for ANOVA.

^bGroups different by least significant difference (LSD test at P<.01.

^cEffect size for comparison of CRF cases and non-cases.

^dHigher values represent better status.

^eHigher values represent poorer status.