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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Wiley Interdiscip Rev Dev Biol. 2013 Jul 25;3(1):113–134. doi: 10.1002/wdev.124

Figure 1. Insulin-nutrition response pathways that regulate growth.

Figure 1

This is the general pathway discussed in the text. Nutrients stimulate the insulin, PTTH/ecdysone and TOR pathways. Although the entire pathway is potentially present in all cells, not all these reactions occur at the same time in development, and different tissues such as fat body and imaginal discs may express different subsets of this complex signaling system. JH can inhibit or direct ecdysone signaling depending on tissue and developmental stage.