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E. coli–B18R reduces interferon (IFN) levels in cancer cells. The effect of bacterial supernatant on IFN-α levels in vesicular stomatitis virus (VSV) infected cell lines was examined by enzyme-linked immunosorbent assay (ELISA). Reductions in IFN-α levels in both (a) 786-O and (b) HT29 cell cultures was evident in E. coli–B18R supernatant and recombinant B18R protein groups. IFN-α–fold increase is shown.
