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Transforming the immunosuppressive IL4 signal into an immunostimulant. Schematic of IL4 signaling through (a) wild-type and (b) chimeric cytokine receptors. (c) Retroviral vector map of chimeric cytokine receptor (IL4/7 ChR). (d) The transgenic expression of IL4/7 ChR on EBV-specific T cells as detected by mOrange and the IL4 receptor exodomain using an anti-IL4 receptor antibody.
