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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Nat Rev Gastroenterol Hepatol. 2013 Jun 25;10(8):473–486. doi: 10.1038/nrgastro.2013.105

Figure 2.

Figure 2

Most of the intrinsic and extrinsic primary afferent neurons that innervate the gut extend processes into the lamina propria of the mucosal layer where they can become exposed to 5-HT released by EC cells185. These include vagal afferent fibers arising from the nodose ganglion, spinal afferent fibers arising from dorsal root ganglia, and intrinsic AH neurons located in submucosal and myenteric ganglia. There is also a class of mechanosensative S neurons in the myenteric ganglia that do not project to the mucosal layer.