Skip to main content
. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Nat Rev Gastroenterol Hepatol. 2013 Jun 25;10(8):473–486. doi: 10.1038/nrgastro.2013.105

Figure 3.

Figure 3

Distribution of 5-HT receptors on enteric neurons, extrinsic nerve fibers and other excitable cells in the gut. At least 6 subtypes of 5-HT receptors are expressed in the wall of the gut, and they can exert excitatory and/or inhibitory influences depending on their location and on the target cell type. a. intrinsic circuits for epithelial secretion and vasodilation. The motor neuron may be the same neuron, but it promotes epithelial secretion and relaxes vascular smooth muscle. b. Intrinsic circuit for propulsive motility. c. extrinsic vagal and spinal afferent fibers. The “+” and “-“ symbols indicate excitatory and inhibitory actions, respectively. References: 5-HT1A171, 186–188; 5-HT1P33, 74, 92, 97, 186, 189–191; 5-HT2129, 130, 192–194; 5-HT333, 74, 81, 106, 112, 116, 117, 119, 123, 124, 152, 186; 5-HT411, 74, 133, 168, 170, 171, 173, 186, 195; 5-HT735, 196.