Table III.

Logistic Analysis of Cumulative Steady-State Carbachol-Induced Dose–Response Curves in Wild Type, Uroplakin II, and Uroplakin IIIa Knockout (KO) Mice

Group	Gender	Emax (g)	pEC50	Slope
WT	Male (11)	3.3 ± 0.5	5.73 ± 0.08	1.0 ± 0.1
	Female (11)	3.7 ± 0.5	5.67 ± 0.08	1.1 ± 0.1
UPII KO	Male (13)	3.3 ± 0.5	5.63 ± 0.07*	1.0 ± 0.1
	Female (11)	3.9 ± 0.5	5.39 ± 0.08**	1.1 ± 0.1
UPIIa KO	Male (14)	3.6 ± 0.4	5.56 ± 0.07	1.3 ± 0.1
	Female (11)	3.0 ± 0.5	5.40 ± 0.08**	1.3 ± 0.1

The number of mice in each category/group was 4. Statistics were based on the number of strips (shown in parentheses). Data are expressed as mean ± SEM. Statistical analysis of differences between groups was performed using Two-way ANOVA followed by post hoc pairwise comparisons. Values of P < 0.05 were taken as statistically significant.

^*Significantly different from UPII KO female.

^**Significantly different from WT female.