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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Biochem Pharmacol. 2013 Jul 4;86(5):656–665. doi: 10.1016/j.bcp.2013.06.025

Figure 3.

Figure 3

Losartan (LOS) inhibits fractional NIC-evoked [3H]DA and [3H]NE release (top) and total [3H]DA and [3H]NE overflow (bottom) from rat striatal and hypothalamic slices, respectively. Arrow indicates the time point at which NIC (10 and 100 μM, for [3H]DA and [3H]NE release assays, respectively) was added to the superfusion buffer. Data are expressed as mean ± S.E.M. Fractional release data are expressed as a percentage of basal. Basal values for fractional [3H]DA and [3H]NE release were 0.76 ± 0.053 and 0.39 ± 0.028% tissue-[3H],respectively. n = 6 rats; **p < 0.01, indicates different from control (0 LOS; effect of NIC in the absence of LOS or MEC).