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. Author manuscript; available in PMC: 2014 Jun 9.
Published in final edited form as: Expert Rev Cardiovasc Ther. 2014 Mar;12(3):383–392. doi: 10.1586/14779072.2014.893191

Figure 5. Immunohistochemistry of the human mitral degenerative valves and calcified tricuspid and bicuspid aortic valves for endochondral signaling markers low-density lipoprotein receptor-related protein 5/Wnt and proliferating cell nuclear antigen.

Figure 5

Control valve, degenerative mitral valve (arrow points to hypertrophic chondrocytes), calcified aortic valves (arrow points to positive stain) and bicuspid aortic valve (arrow points to positive stain; magnification 25×). (A) Lipoprotein receptor-related protein 5 stain. (B) Wnt 3 stain. (C) Proliferating cell nuclear antigen stain [10].

Lrp5: Lipoprotein receptor-related protein 5; PCNA: Proliferating cell nuclear antigen.

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