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. Author manuscript; available in PMC: 2014 Jul 23.
Published in final edited form as: Nature. 2014 Jan 5;505(7484):495–501. doi: 10.1038/nature12912

Figure 1.

Figure 1

Mutation patterns for one known and two novel cancer genes. EGFR shows distinctive tumor-type-specific concentrations of mutations in different regions of the gene. RHEB, which encodes a small GTPase in the RAS superfamily, shows a mutational hotspot in the effector domain. RHOA, another a member of the RAS superfamily, also shows a mutational hotspot in the effector domain. Colored bars after tumor type names are copy-ratio distributions for the gene, when available (red=amplified, blue=deleted). See also Supplementary Figure 4. Similar diagrams for all genes are available at http://www.tumorportal.org.