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. Author manuscript; available in PMC: 2014 Jul 23.
Published in final edited form as: Nature. 2014 Jan 5;505(7484):495–501. doi: 10.1038/nature12912

Figure 2.

Figure 2

Cancer genes in selected tumor types. Genes are arranged on the horizontal line according to p-value (combined value for the three tests in MutSig). Yellow region contains genes that achieve FDR q≤0.1. Orange interval contains p-values for the next 20 genes. Gene name color indicates whether the gene is a known cancer gene (blue), a novel gene with clear connection to cancer (red; discussed in text), or an additional novel gene (black). Circle color indicates the frequency (percent of patients carrying non-silent somatic mutations) in that tumor type. See also Supplementary Figure 5.