Skip to main content
. Author manuscript; available in PMC: 2015 Apr 24.
Published in final edited form as: Mol Cell. 2014 Apr 24;54(2):281–288. doi: 10.1016/j.molcel.2014.03.030

FIGURE 2. Stress and Defense Response Components of Inflammation.

FIGURE 2

Inflammation can be induced by sensing extreme deviations from tissue homeostasis or by sensing the challenges that can cause extreme deviations of tissue homeostasis. The former are detected by sensors of regulated variables of cellular and tissue homeostasis. The latter can be induced upon direct recognition of structural features of agents that can disrupt tissue homeostasis (e.g., PAMP recognition by PRRs) or by detecting their conserved functional features, such as protease activity or chemical reactivity.