Figure 5. Binding of IKKβ to SNAP23 is reduced following E. coli exposure.
(A) RBLs were incubated with or without (control) E. coli at an MOI of 10,000 for 2h. The cells were harvested and stimulated for 30min with 1μM PMA/1μM Ionomycin at a concentration of 2×106 cells/ml, lysed and SNAP23 was immunoprecipitated from 1mg of total protein. Immunoprecipitated samples and 40μg of whole cell lysates were analyzed by Western blot with anti-SNAP23 and -IKKβ antibodies. (B) Graph represents the mean band intensity ratio of IKKβ to total SNAP23 ± the standard deviation of 3 independent experiments. The IKKβ/SNAP23 ratio of the control population was considered 100%. Asterisks denote statistically significant p values, where ** ≤ 0.01.