Skip to main content
. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Neuropharmacology. 2013 Sep 8;76(0 0):97–105. doi: 10.1016/j.neuropharm.2013.08.033

Figure 2. VMAT2 LO mice have reduced brain catecholamines and increased catecholamine turnover at 2 months of age.

Figure 2

A and B: NE and DA content varied with respect to genotype (n=4). A, Brain NE was reduced in the cortex and striatum of VMAT2 LO mice. B, DA was reduced in the striatum of VMAT2 LO animals; DA content in the cortex trended toward reduction. C and D, In all brain regions surveyed, VMAT2 LO mice exhibited increased relative conversion of NE (C) and DA (D) to their metabolites DHPG and DOPAC, respectively. Results represent the mean ± SEM for 4 animals per genotype at each age. *p<0.05, **p<0.01, ***p<0.001.