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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Neuropharmacology. 2013 Sep 8;76(0 0):97–105. doi: 10.1016/j.neuropharm.2013.08.033

Figure 4. VMAT2 LO animals undergo progressive catecholaminergic cell loss.

Figure 4

Immunohistochemical analysis of tyrosine hydroxylase in locus ceruleus of aged VMAT2 LO mice. TH immunoreactivity was substantially reduced in VMAT2 LO mice at 18, 24, and 30 months of age, preceding loss observed in the substantia nigra. Analysis was performed on 5 animals per genotype at each age. Representative sections are shown. Scale bars, 500 µm.