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. 2014 Jun 3;5(3):e01262-14. doi: 10.1128/mBio.01262-14

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Copyright © 2014 Gengenbacher et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

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FIG 2 — Deletion of pdx1 improved the superior safety profile of parental BCG ΔureC::hly over that of canonical BCG in SCID mice. Survival of SCID mice s.c. vaccinated with 10⁶ CFU of indicated strains was monitored over time. Selected groups received vitamin B₆ (VB6)-enriched diet from 2 weeks prior to vaccination to the end of the experiment. Median times of survival were 162.5 days (BCG) and 430 days (BCG ΔureC::hly). Data shown were analyzed using the Mantel-Cox log-rank test. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. Experiment was performed twice.