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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Free Radic Biol Med. 2014 Apr 4;0:368–378. doi: 10.1016/j.freeradbiomed.2014.03.038

TABLE 2.

Published observations on incidences of age-related pathologies in antioxidant mutant mice.

REDUCED expression
Enzyme Cancer Cardiovascular Metabolic Neuronal Refs
Sod1−/− ↑ ↑ ↑ (47, 94, 96, 97)
Sod2+/− ↑ ↑ ↑ ↑ (37, 64, 65, 67)
Gpx1−/− ↑ ↑ ↓ ↓↑ (40, 69–73)
MsrA−/− ↑ ↑ ↑ (44, 74–78)
INCREASED expression
Sod1 TG ↓ ↓ ↓ (79–82)
Sod2 TG - ↓ ↓ ↓ (53, 54, 80, 83–85)
Gpx4 TG ↓ ↓ (86, 87)
Trx1 TG ↑ ↓ ↓ ↓ (56, 88–93)
mCAT TG ↓ ↓ ↓ ↓ (98–103)

↑ = increased incidence of pathology reported, ↓ = reduced incidence of pathology reported, ↓↑ = both increased and reduced incidence of pathology reported, - = no difference reported. Shaded boxes = no data published on pathological state for given model.