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. Author manuscript; available in PMC: 2014 Jun 9.
Published in final edited form as: J Immunol. 2009 Feb 15;182(4):2305–2312. doi: 10.4049/jimmunol.0801980

FIGURE 5.

FIGURE 5

Characteristic features of neutralizing antibodies and B cells of MyD88−/− mice following oral administration of RASV. (a) At 1 month after second immunization, groups of mice were challenged orally with a lethal dose of Salmonella UK-1 strain (1×107 CFU per head) and survival monitored. ** ; p<0.01, *** ; p<0.001 vs. wild-type (WT) mice. (b) Sera and B cells were isolated from MyD88−/− mice 14 days after 2nd oral vaccination with RASV and reconstituted to naïve BALB/c mice. At 1 day after reconstitution, groups of mice were orally challenged with a lethal dose of virulent UK-1 strain and survival was monitored. * ; p<0.05, ** ; p<0.05 and *** ; p<0.001 vs. mice in non-treated group (nil).