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. Author manuscript; available in PMC: 2014 Jun 9.
Published in final edited form as: J Immunol. 2009 Feb 15;182(4):2305–2312. doi: 10.4049/jimmunol.0801980

FIGURE 6.

FIGURE 6

Functional role of MyD88−/− B cells for induction of LPS-specific immunoglobulin responses. (a) The B cells were isolated from naïve WT and MyD88−/− mice and reconstituted to µMT−/− mice (4×107 cells/mouse). One day after B cells transfer, B220+ B cells in CD45+ PBMC were analyzed by flowcytometry Then, the recipient µMT−/− mice were immunized with RASV and splenic B cells were analyzed at 4 wks after vaccination by flow cytometry and immunohistochemistry. b, At 1 day after reconstitution, groups of mice were orally administered RASV twice at 2-week intervals and LPS-specific IgG in sera and IgA in fecal extracts measured. Values are mean ± SD. Data are representative of ≥2 independent experiments.