Table 5a.

Beta weights and Confidence Intervals for Disease and Sex Effects for the Matched Emotions versus the Matched Forms Contrast (ME-MF).

Matching Emotions –Matching Forms (ME-MF)
	Male HC		Female HC		Male IBS		Female IBS
	Beta	CI (L-U)	Beta	CI (L-U)	Beta	CI (L-U)	Beta	CI (L-U)
A. Affective Limbic Circuit
sgACC → AMYG	−0.13	−0.67	−0.18	−0.58	0.25	−0.51	−0.24	−0.86
		0.25		0.14		0.77		1.01
AMYG → sgACC	0.13	−0.14	−0.19	−0.84	0.24	−0.26	−0.23	−0.70
		0.42		0.14		1.00		0.51
sgACC → pACC/vmPFC	0.51	0.08	0.54	0.26	0.48	0.11	1.39	0.53
		1.00		1.03		1.21		2.17
pACC/vmPFC → AMYG	−0.20	−0.61	0.11	−0.50	−0.39	−1.38	0.24	−0.75
		0.21		0.52		0.49		0.71
pACC/vmPFC → aINS	0.16	−0.33	−0.13	−0.41	0.58	−0.59	0.25	−0.09
		0.57		0.37		1.39		0.71
sgACC → aMCC	0.16	−0.14	0.01	0.23	−0.13	0.58	−0.44	−1.04
		0.43		0.23		0.92		0.00
aMCC → aINS	0.82	0.25	0.42	0.01	0.99	…	0.41	0.07
		1.71		0.74		1.45		0.81
AMYG → aINS	−0.20	−0.76	0.01	−0.36	0.09	−0.48	0.02	−0.55
		0.43		0.42		0.97		0.53
aINS → AMYG	0.52	−0.01	0.40	−0.22	0.39	…	0.78	−0.35
		0.83		0.91		0.58		1.37
B. Prefrontal and Hippocampal Modulatory Input to Affective Limbic Circuit
dlPFC →pACC/vmPFC (to amyg)	−0.12	−0.59	−0.22	−0.62	0.03	−0.28	0.78	−0.59
		0.18		0.15		0.73		1.89
vlPFC → pACC/vmPFC (to amyg)	0.06	−0.62	−0.05	−0.74	0.24	…	−0.01	−0.69
		1.22		0.39		0.59		0.77
HIPP → AMYG	0.78	−0.09	0.32	−0.25	−0.03	−0.84	−0.14	−1.06
		1.54		1.05		1.00		2.18
AMYG → HIPP	0.16	−0.01	0.04	−0.29	0.16	−0.18	0.64	−0.79
		0.39		0.25		0.54		1.49
C. Intrainsular Connectivity
pINS → mINS	0.41	0.24	0.57	0.22	0.60	0.20	0.57	0.15
		0.56		1.09		1.14		1.08
mINS → aINS	0.89	−0.01	−0.04	−0.58	0.29	−0.86	0.12	−0.53
		1.95		0.33		1.48		0.79
sgACC → aINS	−0.28	−0.59	−0.04	−0.41	−0.43	−1.47	−0.27	−0.69
		0.11		0.22		0.59		0.22
D. Intracingulate Connectivity
AMYG → pACC/vmPFC	−0.01	−0.45	0.07	−0.30	−0.46	−0.87	−0.24	−0.94
		0.53		0.57		…		2.25
pACC/vmPFC → aMCC	−0.19	−0.45	0.00	−0.42	0.69	−0.27	0.38	−0.30
		0.13		0.35		1.66		0.63
aMCC → PCC	0.00	−0.46	0.21	−0.27	0.51	−0.29	0.72	0.29
		0.82		0.83		0.79		1.12

Critical Values: Uncorrected: χ²=6.63, p < .01, χ²=3.84, p < .05; significance after FDR corrected:

^**p < .01 corrected,

^*p < .05 corrected (Male IBS vs. Female IBS, Male HC vs. Female HC, df=1)

Bootstrapped CI(L-U): confidence interval- lower to upper limit, 95% bias corrected

Beta weights: weak (β=0 to.30), moderate (β=30 to.80), or strong (β= >.80).

… When AMOS was unable to estimate the upper or lower bound confidence limits

Regions: AMYG, amygdala; aINS, mINS, mid insula; pINS, posterior insula; HIPP, hippocampus, aMCC, anterior mid cingulate cortex; sgACC, subgenual cingulate cortex; PCC, posterior cingulate cortex; pACC, pregenual cingulate cortex; vmPFC, ventro-medial prefrontal cortex; dlPFC, dorsolateral prefrontal cortex; vlPFC, ventro-lateral prefrontal cortex

Groups: IBS, Irritable bowel syndrome; HC, Healthy Control

Contrasts: ME, matching emotions; MF, matching forms