Table 5b.

χ² differences Disease and Sex Effects for the Matched Emotions versus the Matched Forms Contrast (ME-MF).

Matching Emotions-Matching Forms (ME-MF)
	Male IBS vs. Female IBS X2 difference	Male IBS vs. Male HC X2 difference	Female IBS vs. Female HC X2 difference
A. Affective Limbic Circuit
sgACC → AMYG	3.9	2.5	0.0
AMYG → sgACC	3.2	0.2	0.0
sgACC → pACC/vmPFC	13.5**	0.0	11.7**
pACC/vmPFC → AMYG	5.6	0.5	0.4
pACC/vmPFC → aINS	0.6	0.9	7.6**
sgACC → aMCC	1.9	2.3	7.2**
aMCC → aINS	4.4	0.3	0.0
AMYG → aINS	0.1	0.9	0.0
aINS → AMYG	2.6	0.5	2.2
B. Prefrontal and Hippocampal Modulatory Input to Affective Limbic Circuit
dlPFC → pACC/vmPFC (to amyg)	5.9	1.0	8.2**
vlPFC → pACC/vmPFC (to amyg)	0.9	0.5	0.0
HIPP → AMYG	0.2	4.5	3.8
AMYG → HIPP	9.3**	0.0	13.0**
C. Intrainsular Connectivity
pINS → mINS	0.0	1.0	0.0
mINS → aINS	0.2	1.5	0.6
sgACC → aINS	0.3	0.0	0.0
D. Intracingulate Connectivity
AMYG → pACC/vmPFC	0.4	2.4	1.0
pACC/vmPFC → aMCC	1.3	10.8**	9.3**
aMCC → PCC	1.3	6.5	6.9**

Significance: Uncorrected: χ²=6.63, p < .01, χ²=3.84, p < .05; significance after FDR corrected:

^**p < .01 corrected,

^*p < .05 corrected (Male IBS vs. Female IBS, Male HC vs. Female HC, df=1)

FDR: False discovery rate (controlling false discovery rate at 5%)

Regions: AMYG, amygdala; aINS, mINS, mid insula; pINS, posterior insula; HIPP, hippocampus, aMCC, anterior mid cingulate cortex; sgACC, subgenual cingulate cortex; PCC, posterior cingulate cortex; pACC, pregenual cingulate cortex; vmPFC, ventro-medial prefrontal cortex; dlPFC, dorsolateral prefrontal cortex; vlPFC, ventro-lateral prefrontal cortex

Groups: IBS, Irritable bowel syndrome; HC, Healthy Control

Contrasts: ME, matching emotions; MF, matching forms