Table 1.
Ion channel mRNAs identified as FMRP targets
| Voltage-gated potassium channels | ||||
| Name | Gene | Type | Notes | Reference |
| KV1.2 | KCNA2 | delayed rectifier | d | |
| KV2.1 | KCNB1 | delayed rectifier | d | |
| KV3.1 | KCNC1 | delayed rectifier | a, confirmed in ref. e | |
| KV3.3 | KCNC3 | A-type | d | |
| KV4.2 | KCND2 | A-type | d, confirmed in ref. f and g | |
| KV10.1 | KCNH1 | delayed rectifier | EAG-related | d |
| KV12.2 | KCNH3 | fast (partial) inactivation | EAG-related | d |
| KV11.3 | KCNH7 | fast (partial) inactivation | EAG-related | d |
| KV7.2 | KCNQ2 | delayed rectifier | M-current | d |
| KV7.3 | KCNQ3 | delayed rectifier | M-current | d |
| Other potassium channels | ||||
| Name | Gene | Type | Notes | Reference |
| KCa1.1 | KNCMA1 | calcium-activated | BK, Maxi-K channel | d |
| KCa4.1 | KCNT1 | sodium-activated | Slack | d |
| KIR3.3 | KCNJ9 | G-protein coupled inward rectifier | GIRK3 | c |
| Voltage-gated sodium channels | ||||
| Name | Gene | Type | Notes | Reference |
| NaV1.1 | SCN2A | TTX-sensitive | d | |
| NaV1.6 | SCN8A | TTX-sensitive | d | |
| Voltage-gated calcium channels | ||||
| Name | Gene | Type | Notes | Reference |
| CaV2.1 | CACNA1A | P/Q-type calcium channel | High voltage-activated | d |
| CaV2.2 | CACNA1B | N-type calcium channel | High voltage-activated | d |
| CaV2.3 | CACNA1E | R-type calcium channel | Intermediate voltage-activated | d |
| CaV3.1 | CACNA1G | T-type calcium channel | Low voltage-activated | d |
| CaV3.3 | CACNA1I | T-type calcium channel | Low voltage-activated | d |
| CaV1.3 | CACNA1D | L-type calcium channel | High voltage-activated | c |
| CANCB1 | L-type calcium channel β1 subunit | d | ||
| CACNB3 | L-type calcium channel β3 subunit | b | ||
| Other channels | ||||
| Name | Gene | Type | Notes | Reference |
| HCN2 | HCN2 | h-channel | non-specific cation channel | b, d |
| CLCN3 | CLCN3 | chloride channel | d | |
| TRPC4 | TRPC4 | Transient receptor potential channel, subclass C | non-specific cation channel | d |
| TRPM3 | TRPM3 | Transient receptor potential channel, subclass M | non-specific cation channel | d |
| VDAC | VDAC1 | Voltage-dependent anion channel | c | |
| ACCN | ACCN1 | Amiloride-sensitive cation channel | d | |
This table represents mRNAs for channel proteins that can bind to, and therefore be regulated by FMRP. The absence of an mRNA from this table does not however mean that the particular channel is not regulated by FMRP. It may reflect a low abundance of that particular mRNA and therefore not detected by the assay used in the indicated study.