. Author manuscript; available in PMC: 2015 Apr 1.

Published in final edited form as: Biochim Biophys Acta. 2014 Feb 12;1839(4):316–333. doi: 10.1016/j.bbagrm.2014.02.001

Table 2.

Summary of structural studies for CTD-binding proteins.

Protein (binding motif)	Phosphor.	CTD peptide	Conformation	Structure	Refs.
Pin1 (WW) (human PPIase)	Ser2-P, Ser5-P	YpSPTpSPS	trans	Extended coil	[69]
Cgt1 (C. albicans capping enzyme)	Ser5-P	4 repeat	trans	β-Like, looped	[169]
Pcf11 (CID) (yeast termination factor)	Ser2-P	PTSPSYpSPTSPS	trans	β-Spiral	[210,211]
Scp1 (BRCT) (human phosphatase)	Ser5-P	PSYSPTpSPS	trans	Extended coil	[207]
SCAF8 (CID) (human splicing factor)	Ser2-P or Ser5-P	Various	trans	β-Turn	[230]
MCE (human capping enzyme guanyltransferase subunit)	Ser5-P	[(pSPSYSP)T]₃	trans	Extended β-like	[204]
Rtt103 (CID) (yeast exo termination factor)	Ser2-P	4 repeat (binds w/Pcf11)	trans	β-Turn	[212]
Ssu72 (Drosophila CTD phosphatase)	Ser5-P	PTpSPSYS	cis	β-Turn	[205]
Ssu72 (human CTD phosphatase)	Ser5-P	SYSPTpSPSYS	cis	β-Turn	[206]
Nrd1 (CID) (yeast termination factor)	Ser5-P	2 repeat	cis	β-Turn	[213]
Set2 (H3K36 methyltransferase)	Ser2-P, Ser5-P	SPSYpSPTpSPSYpSPTpSPS	?	n.d.	[231,232]

CID = CTD interacting domain; WW = WW-domain; BRCT = BRCA1 C-terminal domain.