Fig. 7.
Connolly surface rendering of the cavity that encompasses the catalytic active site and the S’1-pockets of the C. s. scutulatus molecular models. The cavity models have been color coded based on depth in which blue colored sections represent shallow portions of the cavity while red regions depict deeper areas of the cavity. For visual clarity, the amino acid residues of the three histidine residues of the active site and the methionine residue of the Met turn have been rendered in ball and stick mode. Note that all models have variable shape while the cavity size is shallow and smaller for GP1 metalloproteinase compared to the other three molecular models. The cavity area and volumes were calculated respectively for the four Mojave metalloproteinase models as follows: 277.5 Å2 and 263.81 Å3 for GP1, 427 Å2 and 463 Å3 for GP2, 495 Å2 and 464 Å3 for GP3, 503 Å2 and 391.7 Å3 for GP4, respectively