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. 2014 May 19;13:112. doi: 10.1186/1476-4598-13-112

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Copyright © 2014 Salvo et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Integrin β3 silencing in H157 cells significantly diminishes cell movement across LEC monolayers. (A) Microphotographs showing the adhesion of TGF-β-pretreated H157 cells (integrin-competent and integrin-deficient) to LEC monolayers (63× water objective). (B) Average distance covered and speed of TGF-β-pretreated H157 cells (integrin-competent and integrin-deficient): ** p = 0.001, one-way ANOVA with Dunnett’s multiple comparison test. (C) Representation of cell directionality for one representative cell from each group. A minimum of 30 cells were analyzed per group.