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. 2014 May 19;13:112. doi: 10.1186/1476-4598-13-112

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Copyright © 2014 Salvo et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Combined targeting of TGF-β and integrin β3 attenuates lymph node metastasis of H157 NSCLC cells in the lungs of immunodeficient mice. (A) Percentage of affected lymph nodes (axillary and brachial) in the different experimental groups analyzed. Statistical analyses were performed by means of Mann–Whitney U- test. Significant values are depicted with double asterisks and correspond to p values of 0.009 for both comparisons (B) Representative microphotograph of GFP tumor detection in the histological samples obtained from lungs (upper row) and lymph nodes (lower row). (C) Immunohistochemical detection of integrin β3 in tumors obtained from mice.