Table 1.
Ex vivo susceptibility of Plasmodium falciparum isolates against chloroquine, monodeshethylamodiaquine, quinine, lumefantrine and dihydroartemisinin
| Culture success rate % (n/N) | IC50 mean (nM) [95% CI] |
Range (nM) |
Resistant isolates (%) | ||
|---|---|---|---|---|---|
| Minimum | Maximum | ||||
| Chloroquine |
86.8 (382/440) |
69.2 [60.6 – 79.1] |
8.3 |
595.9 |
161 (42.1) |
| Quinine |
86.8 (382/440) |
162.1 [148.3 – 177.3] |
10.2 |
950.3 |
4 (1.0) |
| Monodesethylamodiaquine |
85.7 (377/440) |
19.3 [18.0 – 20.6] |
0.8 |
595.9 |
24 (6.4) |
| Lumefantrine |
86.8 (382/440) |
25.1 [22.4 – 28.2] |
0.8 |
166.1 |
NA |
| Piperaquine |
79.3 (349/440) |
6.3 [5.9 – 6.8] |
0.8 |
375.2 |
NA |
| Dihydroartemisinin | 86.5 (381/440) | 0.8 [0.8 – 0.9] | 0.1 | 38.8 | NA |
Resistance threshold defined for chloroquine at 100 nM, quinine at 800 nM and monodeshethylamodiaquine at 60 nM; NA: Non applicable as the threshold is not defined yet.