Table 2.
Ex vivo IC 50 of Plasmodium falciparum isolates against monodeshethylamodiaquine, quinine, lumefantrine, piperaquine and dihydroartemisinin by chloroquine susceptibility
| Drug | Chloroquine-resistant isolates (n = 161) | Chloroquine-sensitive isolates (n = 221) | P value |
|---|---|---|---|
| Chloroquine |
289.8 [269.2 – 312.0)] |
24.4 (22.8 – 26.1) |
0.0001 |
| Monodesethylamodiaquine |
33.8 [31.4 – 36.4] |
12.8 [12.0 – 13.6] |
0.0001 |
| Quinine |
249.7 [223.3 – 279.1] |
120.4 [107.2 – 135.2] |
0.0001 |
| Lumefantrine |
21.9 [18.8 – 25.5] |
27.8 [23.5 – 32.8] |
0.0006 |
| Piperaquine |
6.5 [5.7 – 7.3] |
6.1 [5.6 – 6.7] |
0.382 |
| Dihydroartemisinin | 0.7 [0.6 – 0.8] | 0.9 [0.8 – 1.0] | 0.001 |