Table 3.
Pairwise comparison of ex vivo IC 50 values
| Drug pairs | r* | P - value |
|---|---|---|
| Chloroquine - Dihydroartemisinin |
-0.08 |
0.09 |
| Chloroquine - Monodestylamodiaquine |
0.86 |
< 0.0001 |
| Chloroquine – quinine |
0.51 |
< 0.0001 |
| Chloroquine - Piperaquine |
0.02 |
0.63 |
| Chloroquine - Lumefantrine |
-0.10 |
0.03 |
| Dihydroartemisinin- Monodestylamodiaquine |
0.01 |
0.77 |
| Dihydroartemisinin – Quinine |
0.15 |
0.002 |
| Dihydroartemisinin- Piperaquine |
0.27 |
< 0.0001 |
| Dihydroartemisinin - Lumefantrine |
0.30 |
< 0.0001 |
| Monodestylamodiaquine – Quinine |
0.52 |
< 0.0001 |
| Monodestylamodiaquine - Piperaquine |
0.14 |
0.008 |
| Monodestylamodiaquine - Lumefantrine |
-0.11 |
0.025 |
| Quinine - Piperaquine |
0.07 |
0.16 |
| Quinine – Lumefantrine |
0.32 |
< 0.0001 |
| Piperaquine - Lumefantrine | 0.04 | 0.35 |
*Spearman’s rank-order correlation coefficient (r).