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. 2014 Jun 1;6:12. doi: 10.1186/2045-824X-6-12

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Copyright © 2014 Chinchar et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Western blot analysis indicated that sunitinib at 1 μmol/L significantly increased the expression of Notch-1 at 24, 48, and 72 hours of the treatment in cultured MDA-MB-468 cells (A) and MDA-MB-231 cells (B), respectively. In cultured MDA-MB-468 cells, compared to the control group, respectively (n = 4; P < 0.01), in which the densitometry ratio of Notch1/β-actin in sunitinib-group was significantly (P < 0.01) increased by 2.0-fold, 2.5-fold, and 5.7-fold at 24, 48, and 72 hours than the control group, respectively. But, sunitinib at 0.1 μmol/L had no effect on the expression of Notch-1. The similar results were also observed in cultured MDA-MB-231 cells.