Table 2.
Minor allele Frequency | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
| ||||||||||
System | Gene | CHR | SNP/mutation | Minor | Major | n | TOTAL | EA | AA | other |
Dopamine | SPR | 2 | rs2421095 | G | A | 245 | 0.153 | 0.128 | 0.405 | 0.143 |
2 | rs1876487 | A | C | 244 | 0.393 | 0.361 | 0.786 | 0.310 | ||
DRD3 | 3 | rs6280 | A | G | 245 | 0.398 | 0.377 | 0.568 | 0.429 | |
DRD1 | 5 | rs4532 | A | G | 245 | 0.358 | 0.406 | 0.091 | 0.167 | |
DDC | 7 | rs2060762 | A | G | 243 | 0.156 | 0.152 | 0.143 | 0.214 | |
7 | rs11575543* | A | G | 245 | 0.043 | 0.032 | 0.167 | 0.023 | ||
7 | rs11575542* | A | G | 245 | 0.041 | 0.030 | 0.167 | 0.024 | ||
7 | rs11575522* | A | G | 244 | 0.037 | 0.027 | 0.143 | 0.024 | ||
7 | rs11238131 | A | G | 245 | 0.318 | 0.300 | 0.405 | 0.405 | ||
TH | 11 | rs71029110 | 9.3R or 10R | Non 9.3R or 10R | 245 | 0.307 | 0.337 | 0.205 | 0.119 | |
DAT1 | 5 | rs28363170 | Non 10R | 10R | 245 | 0.232 | 0.232 | 0.250 | 0.214 | |
DRD5 | 4 | - | 9R | Non 9R | 226 | 0.398 | 0.431 | 0.237 | 0.237 | |
DBH | 9 | rs77905 | A | G | 245 | 0.473 | 0.510 | 0.310 | 0.286 | |
9 | rs6271 | A | G | 245 | 0.073 | 0.079 | 0.024 | 0.071 | ||
9 | rs1611115 | A | G | 245 | 0.229 | 0.234 | 0.214 | 0.190 | ||
9 | rs1108580 | A | G | 244 | 0.439 | 0.438 | 0.350 | 0.524 | ||
COMT | 22 | rs4580 | A | G | 245 | 0.573 | 0.532 | 0.818 | 0.714 | |
DRD4 | 11 | rs4646984 | 7R | Non 7R | 243 | 0.200 | 0.205 | 0.227 | 0.119 | |
DRD2 | 11 | rs1800497 | A2 | A1 | 245 | 0.203 | 0.187 | 0.318 | 0.238 | |
Dopamine/Serotonin | MAOA | 23 | MAOA-LPR | 3.5R or 4R | Non 3.5R or 4R | 245 | 0.386 | 0.352 | 0.500 | 0.595 |
Serotonin | HTR1A | 5 | rs6295 | C | G | 245 | 0.488 | 0.483 | 0.405 | 0.619 |
5 | rs1800044* | A | C | 245 | 0.006 | 0.007 | 0.000 | 0.000 | ||
5 | rs1799920* | - | G | 243 | 0.000 | 0.000 | 0.000 | 0.000 | ||
5 | rs10042486 | G | A | 245 | 0.471 | 0.502 | 0.357 | 0.286 | ||
HTR1B | 6 | rs6296 | G | C | 245 | 0.251 | 0.236 | 0.262 | 0.381 | |
6 | rs13212041 | G | A | 245 | 0.288 | 0.264 | 0.548 | 0.262 | ||
6 | rs130058 | A | T | 245 | 0.263 | 0.288 | 0.095 | 0.190 | ||
TPH2 | 12 | rs7963720 | G | A | 244 | 0.457 | 0.428 | 0.619 | 0.571 | |
12 | rs7305115 | A | G | 245 | 0.414 | 0.414 | 0.357 | 0.476 | ||
12 | rs4290270 | T | A | 245 | 0.394 | 0.360 | 0.571 | 0.548 | ||
12 | rs17110690 | A | G | 244 | 0.172 | 0.191 | 0.048 | 0.119 | ||
12 | rs1487275 | C | A | 245 | 0.284 | 0.266 | 0.262 | 0.476 | ||
12 | rs17110747 | A | G | 245 | 0.110 | 0.114 | 0.000 | 0.182 | ||
HTR2A | 13 | rs927544 | G | A | 245 | 0.261 | 0.273 | 0.167 | 0.238 | |
13 | rs7997012 | A | G | 245 | 0.343 | 0.372 | 0.095 | 0.310 | ||
13 | rs6314 | A | G | 243 | 0.088 | 0.097 | 0.071 | 0.024 | ||
13 | rs6313 | A | G | 245 | 0.427 | 0.431 | 0.310 | 0.500 | ||
13 | rs6311 | A | G | 237 | 0.439 | 0.446 | 0.310 | 0.500 | ||
13 | rs2770296 | G | A | 244 | 0.283 | 0.295 | 0.238 | 0.214 | ||
13 | rs1923886 | G | A | 245 | 0.365 | 0.394 | 0.095 | 0.357 | ||
SERT | 17 | rs2066713 | A | G | 244 | 0.338 | 0.354 | 0.238 | 0.286 | |
17 | rs2020933* | A | T | 245 | 0.010 | 0.007 | 0.048 | 0.000 | ||
17 | rs16965628 | C | G | 245 | 0.108 | 0.103 | 0.262 | 0.000 | ||
17 | rs1042173 | C | A | 245 | 0.420 | 0.441 | 0.190 | 0.452 | ||
Opioid | OPRD | 1 | rs569356 | G | A | 244 | 0.117 | 0.134 | 0.024 | 0.048 |
1 | rs2236861 | A | G | 244 | 0.182 | 0.204 | 0.000 | 0.143 | ||
1 | rs204076 | T | A | 244 | 0.305 | 0.332 | 0.190 | 0.167 | ||
6 | rs7773995 | A | G | 245 | 0.153 | 0.158 | 0.167 | 0.095 | ||
6 | rs514980 | G | A | 245 | 0.204 | 0.214 | 0.119 | 0.190 | ||
6 | rs2281617* | A | G | 245 | 0.014 | 0.012 | 0.000 | 0.048 | ||
6 | rs1799971 | G | A | 245 | 0.118 | 0.131 | 0.000 | 0.119 | ||
6 | rs12205732 | A | G | 245 | 0.061 | 0.052 | 0.119 | 0.095 | ||
6 | rs10485057 | G | A | 241 | 0.110 | 0.109 | 0.143 | 0.079 | ||
6 | rs17174801* | G | A | 239 | 0.004 | 0.000 | 0.053 | 0.000 |
Excluded based on MAF<0.05