TABLE 1.
HLA-B allele frequencies among T1D cases (transmitted) and controls (AFBAC) and proportion transmitted from heterozygote parents to T1D cases
| HLA-B | Controls (AFBAC) (%) |
T1D (%) | Odds ratio | 95% CI | p Value | Transmitted (%) |
|---|---|---|---|---|---|---|
| 0702 | 16.5 | 8.0 | 0.44 | (0.30–0.66) | 1.E-04 | 37.0 |
| 0704 | 0.3 | 0.0 | — | — | NS | 0.0 |
| 0705 | 0.3 | 1.0 | 3.91 | (0.46–33.02) | NS | 68.8 |
| 0801 | 9.3 | 21.8 | 2.73 | (1.84–4.04) | 3.E-06 | 63.1 |
| 1302 | 1.5 | 0.7 | 0.47 | (0.13–1.66) | NS | 36.4 |
| 1401 | 0.8 | 0.7 | 0.94 | (0.21–4.22) | NS | 44.4 |
| 1402 | 3.3 | 1.1 | 0.34 | (0.13–0.89) | 0.023 | 29.5 |
| 1501 | 4.0 | 12.5 | 3.43 | (1.96–6.00) | 1.E-05 | 68.9 |
| 1503/7/8/10/24a | 0.3 | 0.9 | — | — | NS | 65.0 |
| 1517 | 0.3 | 0.4 | 1.77 | (0.17–18.02) | NS | 50.0 |
| 1518 | 0.8 | 0.0 | — | — | NS | 0.0 |
| 1801 | 5.8 | 8.7 | 1.57 | (0.94–2.61) | NS | 62.7 |
| 2702 | 0.5 | 0.1 | 0.18 | (0.01–3.90) | NS | 16.7 |
| 2703 | 2.3 | 4.2 | 1.92 | (0.88–4.17) | NS | 58.5 |
| 3501 | 7.3 | 3.8 | 0.50 | (0.28–0.89) | 0.020 | 35.3 |
| 3502 | 2.3 | 0.4 | 0.19 | (0.05–0.79) | 0.011 | 20.8 |
| 3503 | 1.0 | 1.1 | 1.15 | (0.33–4.01) | NS | 50.0 |
| 3508 | 0.3 | 0.4 | 1.41 | (0.13–15.62) | NS | 66.7 |
| 3701 | 0.8 | 0.6 | 0.82 | (0.17–3.86) | NS | 37.5 |
| 3801 | 2.8 | 1.9 | 0.67 | (0.28–1.57) | NS | 38.0 |
| 3901 | 1.3 | 1.3 | 1.06 | (0.34–3.31) | NS | 50.0 |
| 3903 | 0.3 | 0.0 | — | — | NS | 0.0 |
| 3906 | 0.8 | 3.8 | 5.21 | (1.55–17.56) | 0.003 | 86.0 |
| 4001 | 6.5 | 7.2 | 1.11 | (0.66–1.84) | NS | 52.6 |
| 4002 | 1.0 | 0.7 | 0.70 | (0.17–2.83) | NS | 40.9 |
| 4101 | 0.3 | 0.9 | 3.55 | (0.41–30.48) | NS | 62.5 |
| 4202 | 0.3 | 0.0 | — | — | NS | 0.0 |
| 4402 | 7.5 | 6.8 | 0.90 | (0.55–1.47) | NS | 47.0 |
| 4403 | 4.8 | 1.8 | 0.36 | (0.17–0.78) | 0.008 | 29.4 |
| 4404 | 0.0 | 0.1 | — | — | NS | 50.0 |
| 4501 | 0.3 | 0.6 | 2.48 | (0.27–22.94) | NS | 58.3 |
| 4701 | 0.3 | 0.4 | 1.77 | (0.17–18.02) | NS | 62.5 |
| 4801 | 0.0 | 0.1 | — | — | NS | 50.0 |
| 4901 | 0.8 | 1.1 | 1.41 | (0.35–5.69) | NS | 54.5 |
| 5001 | 1.3 | 1.6 | 1.27 | (0.42–3.83) | NS | 50.0 |
| 5002 | 0.3 | 0.0 | — | — | NS | 0.0 |
| 5101 | 4.0 | 2.7 | 0.65 | (0.32–1.33) | NS | 45.5 |
| 5108 | 0.3 | 0.1 | 0.35 | (0.01–10.52) | NS | 25.0 |
| 5201 | 0.5 | 0.4 | 0.70 | (0.10–5.02) | NS | 40.0 |
| 5301 | 1.0 | 0.3 | 0.26 | (0.04–1.72) | NS | 25.0 |
| 5501 | 1.5 | 0.6 | 0.41 | (0.11–1.53) | NS | 31.8 |
| 5601 | 1.0 | 0.6 | 0.61 | (0.15–2.59) | NS | 38.9 |
| 5701 | 5.3 | 0.4 | 0.08 | (0.02–0.30) | 2.E-06 | 9.3 |
| 5703 | 0.3 | 0.2 | 0.70 | (0.04–11.30) | NS | 50.0 |
| 5801 | 0.8 | 0.0 | — | — | NS | 0.0 |
Abbreviations: AFBAC = affected family-based control; CI = confidence interval; HLA = human leukocyte antigen; NS = not significant; T1D = type 1 diabetes.
a
These low-frequency alleles were grouped together for brevity.