TABLE 10.
HLA-B, HLA-C, and B-C allele frequencies among transmitted and nontransmitted DR3, DR4, DR1, and DR8 haplotypes to patients with T1D
| DRB1*0301 total chromosomes HLA-B |
DQB1*02 Not trans = 164 Freq NT |
trans = 347 Freq trans |
p Value | Trans% 67.9% % Trans |
HLA-C | Freq NT | Freq trans | p Value | % Trans | HLA-B | HLA-C | Freq NT | Freq trans | p Value | % Trans |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0702 | 2.4% | 5.5% | NS | 82.6% | 0202 | 1.8% | 0.9% | NS | 50.0% | 0702 | 0702 | 2.4% | 5.5% | NS | 82.6% |
| 0801 | 69.5% | 60.5% | NS | 64.8% | 0303 | 2.4% | 1.7% | NS | 60.0% | 0801 | 0701 | 67.1% | 58.2% | NS | 64.7% |
| 1501 | 1.8% | 0.9% | NS | 50.0% | 0304 | 2.4% | 2.3% | NS | 66.7% | 0801 | 0702 | 0.6% | 1.4% | NS | 83.3% |
| 1801 | 9.8% | 19.6% | 0.010 | 81.0% | 0401 | 1.2% | 2.9% | NS | 83.3% | 1801 | 0501 | 9.1% | 17.6% | 0.021 | 80.3% |
| 2703 | 2.4% | 1.2% | NS | 50.0% | 0501 | 11.0% | 18.2% | 0.057 | 77.8% | 3501 | 0401 | 0.6% | 1.4% | NS | 83.3% |
| 3501 | 0.6% | 1.4% | NS | 83.3% | 0602 | 4.3% | 4.3% | NS | 68.2% | 5001 | 0602 | 3.7% | 2.6% | NS | 60.0% |
| 5001 | 3.7% | 2.6% | NS | 60.0% | 0701 | 68.3% | 58.8% | NS | 64.6% | — | Other | 16.5% | 13.3% | — | — |
| 5101 | 1.2% | 1.4% | NS | 71.4% | 0702 | 3.0% | 6.9% | 0.087 | 82.8% | — | — | — | — | — | — |
| Other | 8.5% | 6.9% | — | — | Other | 5.5% | 4.0% | — | — | — | — | — | — | — | — |
| DRB1*0404 total chromosomes HLA-B |
DQB1*0302 Not trans = 41, trans = 106 Freq NT |
trans = 106 Freq trans |
p Value | Trans% 72.1% % Trans |
HLA-C | Freq NT | Freq trans | p Value | % Trans | HLA-B | HLA-C | Freq NT | Freq trans | p Value | % Trans |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0702 | 2.4% | 14.2% | 0.054 | 93.8% | 0202 | 7.3% | 4.7% | NS | 62.5% | 0702 | 0702 | 2.4% | 14.2% | 0.054 | 93.8% |
| 0801 | 0.0% | 9.4% | 0.092 | 100.0% | 0303 | 14.6% | 7.5% | NS | 57.1% | 0801 | 0701 | 0.0% | 9.4% | 0.095 | 100.0% |
| 1501 | 9.8% | 7.5% | NS | 66.7% | 0304 | 41.5% | 27.4% | NS | 63.0% | 1501 | 0303 | 9.8% | 4.7% | NS | 55.6% |
| 2703 | 9.8% | 5.7% | NS | 60.0% | 0401 | 4.9% | 3.8% | NS | 66.7% | 2703 | 0202 | 7.3% | 4.7% | NS | 62.5% |
| 3906 | 4.9% | 7.5% | NS | 80.0% | 0501 | 0.0% | 7.5% | NS | 100.0% | 3906 | 0702 | 4.9% | 7.5% | NS | 80.0% |
| 4001 | 41.5% | 28.3% | NS | 63.8% | 0701 | 0.0% | 13.2% | 0.038 | 100.0% | 4001 | 0304 | 41.5% | 26.4% | NS | 62.2% |
| 4402 | 4.9% | 7.5% | NS | 80.0% | 0702 | 7.3% | 23.6% | 0.043 | 89.3% | 4402 | 0501 | 0.0% | 7.5% | NS | 100.0% |
| 5101 | 12.2% | 6.6% | NS | 58.3% | 1203 | 2.4% | 4.7% | NS | 83.3% | 5101 | 1502 | 12.2% | 4.7% | NS | 50.0% |
| Other | 14.6% | 13.2% | — | — | 1502 | 12.2% | 4.7% | NS | 50.0% | — | Other | 22.0% | 20.8% | — | — |
| — | — | — | — | — | Other | 9.8% | 2.8% | — | — | — | — | — | — | — | — |
| DRB1*0401 total chromosomes HLA-B |
DQB1*0302 Not trans = 78, Freq NT |
trans = 259 Freq trans |
p Value | Trans% 76.9% % Trans |
HLA-C | Freq NT | Freq trans | p Value | % Trans | HLA-B | HLA-C | Freq NT | Freq trans | p Value | % Trans |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0702 | 3.8% | 8.9% | NS | 88.5% | 0102 | 3.8% | 2.3% | NS | 66.7% | 0702 | 0702 | 3.8% | 8.1% | NS | 87.5% |
| 0801 | 1.3% | 3.5% | NS | 90.0% | 0202 | 0.0% | 5.4% | 0.075 | 100.0% | 0801 | 0701 | 1.3% | 3.5% | NS | 90.0% |
| 1302 | 0.0% | 1.9% | NS | 100.0% | 0303 | 9.0% | 16.2% | NS | 85.7% | 1302 | 0602 | 0.0% | 1.9% | NS | 100.0% |
| 1501 | 43.6% | 40.5% | NS | 75.5% | 0304 | 38.5% | 32.8% | NS | 73.9% | 1501 | 0303 | 7.7% | 12.0% | NS | 83.8% |
| 1801 | 5.1% | 3.5% | NS | 69.2% | 0401 | 7.7% | 3.5% | NS | 60.0% | 1501 | 0304 | 29.5% | 25.5% | NS | 74.2% |
| 2703 | 1.3% | 7.3% | 0.054 | 95.0% | 0501 | 11.5% | 7.3% | NS | 67.9% | 1801 | 1203 | 1.3% | 3.1% | NS | 88.9% |
| 3501 | 3.8% | 1.2% | NS | 50.0% | 0602 | 1.3% | 3.1% | NS | 88.9% | 2703 | 0202 | 0.0% | 4.6% | NS | 100.0% |
| 3801 | 5.1% | 0.8% | 0.011 | 33.3% | 0701 | 6.4% | 5.8% | NS | 75.0% | 2703 | 0303 | 1.3% | 1.9% | NS | 83.3% |
| 4001 | 9.0% | 8.1% | NS | 75.0% | 0702 | 3.8% | 9.7% | NS | 89.3% | 3501 | 0401 | 3.8% | 1.2% | NS | 50.0% |
| 4402 | 11.5% | 8.9% | NS | 71.9% | 0704 | 2.6% | 1.5% | NS | 66.7% | 3801 | 1203 | 5.1% | 0.8% | 0.011 | 33.3% |
| 4403 | 2.6% | 3.1% | NS | 80.0% | 1203 | 7.7% | 5.8% | NS | 71.4% | 4001 | 0304 | 9.0% | 7.3% | NS | 73.1% |
| 5101 | 2.6% | 1.5% | NS | 66.7% | Other | 7.7% | 6.6% | — | — | 4402 | 0501 | 9.0% | 7.3% | NS | 73.1% |
| 5601 | 3.8% | 2.3% | NS | 66.7% | — | — | — | — | — | 4402 | 0704 | 2.6% | 1.5% | NS | 66.7% |
| Other | 6.4% | 8.5% | — | — | — | — | — | — | — | 5601 | 0102 | 3.8% | 2.3% | NS | 66.7% |
| — | — | — | — | — | — | — | — | — | — | — | Other | 21.8% | 18.9% | — | — |
| DRB1*0801 total chromosomes HLA-B |
DQB1*0402 Not trans = 21, Freq NT |
trans = 32 Freq trans |
p Value | 60.4% % Trans |
HLA-C | Freq NT | Freq trans | p Value | % Trans | HLA-B | HLA-C | Freq NT | Freq trans | p Value | % Trans |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2703 | 23.8% | 15.6% | NS | 50.0% | 0102 | 9.5% | 12.5% | NS | 66.7% | 2703 | 0102 | 9.5% | 12.5% | NS | 66.7% |
| 3906 | 4.8% | 59.4% | 0.002 | 95.0% | 0304 | 14.3% | 12.5% | NS | 57.1% | 3906 | 0702 | 4.8% | 59.4% | 0.002 | 95.0% |
| 4001 | 9.5% | 12.5% | NS | 66.7% | 0401 | 19.0% | 12.5% | NS | 50.0% | 4001 | 0304 | 9.5% | 12.5% | NS | 66.7% |
| Other | 61.9% | 12.5% | — | — | 0702 | 23.8% | 59.4% | 0.060 | 79.2% | — | Other | 76.2% | 15.6% | — | — |
| — | — | — | — | — | Other | 33.3% | 3.1% | — | — | — | — | — | — | — | — |
| DRB1*0101 total chromosomes HLA-B |
DQB1*0501 Not trans = 85, Freq NT |
trans = 72 Freq trans |
p Value | Trans% 45.9% % Trans |
HLA-C | Freq NT | Freq trans | p Value | % Trans | HLA-B | HLA-C | Freq NT | Freq trans | p Value | % Trans |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0702 | 18.8% | 11.1% | NS | 33.3% | 0102 | 8.2% | 5.6% | NS | 36.4% | 0702 | 0702 | 18.8% | 11.1% | NS | 33.3% |
| 0801 | 3.5% | 6.9% | NS | 62.5% | 0304 | 15.3% | 4.2% | 0.030 | 18.8% | 0801 | 0701 | 3.5% | 6.9% | NS | 62.5% |
| 1501 | 4.7% | 5.6% | NS | 50.0% | 0401 | 25.9% | 18.1% | NS | 37.1% | 2703 | 0102 | 3.5% | 8.3% | NS | 66.7% |
| 2703 | 5.9% | 12.5% | NS | 64.3% | 0501 | 5.9% | 4.2% | NS | 37.5% | 2703 | 0202 | 2.4% | 4.2% | NS | 60.0% |
| 3501 | 24.7% | 18.1% | NS | 38.2% | 0701 | 8.2% | 2.8% | NS | 22.2% | 3501 | 0401 | 22.4% | 18.1% | NS | 40.6% |
| 3906 | 2.4% | 11.1% | 0.030 | 80.0% | 0702 | 23.5% | 13.9% | NS | 33.3% | 3906 | 0702 | 2.4% | 11.1% | 0.030 | 80.0% |
| 4001 | 12.9% | 4.2% | 0.067 | 21.4% | Other | 12.9% | 51.4% | — | — | 4001 | 0304 | 12.9% | 4.2% | 0.067 | 21.4% |
| 4402 | 8.2% | 11.1% | NS | 53.3% | — | — | — | — | — | 4402 | 0501 | 5.9% | 4.2% | NS | 37.5% |
| Other | 18.8% | 19.4% | — | 45.9% | — | — | — | — | — | — | Other | 28.2% | 31.9% | — | — |
Abbreviations: Freq NT = frequency nontransmitted; Freq trans = frequency transmitted; HLA = human leukocyte antigen.