TABLE 11.

Mean age at onset of disease by genotype for HLA-B and HLA-C alleles associated with T1D susceptibility

Genotype	Age at onset of patients carrying genotype (y)	Standard error	Age at onset of patients not carrying genotype (y)	Standard error	F a	p Value
All patients	11.55	0.32	—	—	—	—
B*1801 +	10.83	0.80	11.70	0.36	0.99	NS
B*3906+	7.84	1.19	11.85	0.34	10.46	<0.0013
B*4403 +	15.10	1.72	11.42	0.33	4.42	<0.036
C*0303 +	11.59	0.93	11.53	0.35	0.00	NS
C*0701 +	11.57	0.48	11.54	0.44	0.00	NS
C*0702 +	9.54	0.67	12.16	0.37	11.59	<0.0007
C*0702 + B*3906−	10.19	0.81	12.20	0.37	4.99a	<0.026
C*0802	13.26	1.87	11.50	0.33	0.86	NS
C*1601	12.29	2.06	11.53	0.33	0.13	NS

See Table 1 for abbreviations.

^aFor all tests, F_(1,551), except C*0702 + B*3906−, for which F_(1,510).