TABLE 6.
Linkage disequilibrium between class II DRB1-DQB1 haplotypes and class I HLAC alleles among controlsa
| DRB1 | DQB1 | HLA-C | DR-DQ frequency (%) |
HLA-C frequency (%) |
DR-DQ-C frequency (%) |
Dij | D ′ | p Value |
|---|---|---|---|---|---|---|---|---|
| 1501 | 0602 | 0702 | 15.8 | 18.5 | 9.52 | 0.066 | 0.513 | 1.3E-14 |
| 0301 | 02 | 0701 | 9.5 | 13.0 | 7.02 | 0.058 | 0.698 | 3.7E-25 |
| 0701 | 02 | 1601 | 10.3 | 3.8 | 3.26 | 0.029 | 0.851 | 2.6E-20 |
| 0701 | 02 | 0602 | 10.3 | 10.0 | 2.51 | 0.015 | 0.164 | 0.004 |
| 0101 | 0501 | 0401 | 7.5 | 10.5 | 2.01 | 0.012 | 0.181 | 0.006 |
| 1302 | 0604 | 0304 | 3.3 | 9.0 | 1.50 | 0.012 | 0.408 | 8.2E-06 |
| 0401 | 0302 | 0304 | 3.5 | 9.0 | 1.50 | 0.012 | 0.372 | 2.5E-05 |
| 0404 | 0302 | 0304 | 3.3 | 9.0 | 1.50 | 0.012 | 0.408 | 8.2E-06 |
| 0101 | 0501 | 0304 | 7.5 | 9.0 | 1.50 | 0.008 | 0.121 | 0.045 |
| 0401 | 0301 | 0501 | 4.5 | 7.8 | 1.50 | 0.012 | 0.277 | 9.9E-05 |
| 0101 | 0501 | 0702 | 7.5 | 18.5 | 1.50 | 0.001 | 0.018 | NS |
| 1501 | 0602 | 1203 | 15.8 | 6.5 | 1.50 | 0.005 | 0.087 | NS |
| 0701 | 02 | 0401 | 10.3 | 10.5 | 1.25 | 0.002 | 0.019 | NS |
| 0701 | 02 | 0802 | 10.3 | 4.3 | 1.25 | 0.008 | 0.214 | 0.014 |
| 1501 | 0602 | 0401 | 15.8 | 10.5 | 1.00 | −0.007 | −0.395 | NS |
| 1501 | 0602 | 0501 | 15.8 | 7.8 | 1.00 | −0.002 | −0.181 | NS |
| 0301 | 02 | 0501 | 9.5 | 7.8 | 1.00 | 0.003 | 0.038 | NS |
| 1301 | 0603 | 1203 | 5.8 | 6.5 | 1.00 | 0.006 | 0.116 | 0.041 |
| 0402 | 0302 | 1203 | 2.3 | 6.5 | 1.00 | 0.009 | 0.406 | 8.2E-06 |
| 1101 | 0301 | 0102 | 4.8 | 2.3 | 0.75 | 0.006 | 0.300 | 8.5E-05 |
| 1301 | 0603 | 0303 | 5.8 | 2.5 | 0.75 | 0.006 | 0.257 | 0.002 |
| 0401 | 0301 | 0304 | 4.5 | 9.0 | 0.75 | 0.003 | 0.084 | NS |
| 0701 | 02 | 0304 | 10.3 | 9.0 | 0.75 | −0.002 | −0.187 | NS |
| 1101 | 0301 | 0401 | 4.8 | 10.5 | 0.75 | 0.003 | 0.059 | NS |
| 1301 | 0603 | 0401 | 5.8 | 10.5 | 0.75 | 0.001 | 0.028 | NS |
| 1301 | 0603 | 0501 | 5.8 | 7.8 | 0.75 | 0.003 | 0.057 | NS |
| 1501 | 0602 | 0602 | 15.8 | 10.0 | 0.75 | −0.008 | −0.524 | NS |
| 1501 | 0602 | 0701 | 15.8 | 13.0 | 0.75 | −0.013 | −0.634 | NS |
| 0101 | 0501 | 0701 | 7.5 | 13.0 | 0.75 | −0.002 | −0.231 | NS |
| 1104 | 0301 | 0701 | 3.3 | 13.0 | 0.75 | 0.003 | 0.116 | NS |
| 0401 | 0301 | 0702 | 4.5 | 18.5 | 0.75 | −0.001 | −0.099 | NS |
| 1302 | 0604 | 0702 | 3.3 | 18.5 | 0.75 | 0.001 | 0.056 | NS |
| 1104 | 0301 | 1203 | 3.3 | 6.5 | 0.75 | 0.005 | 0.177 | 0.019 |
| 1101 | 0301 | 1203 | 4.8 | 6.5 | 0.75 | 0.004 | 0.099 | NS |
See Table 1 for abbreviations.
Only haplotypes with a frequency of at least 0.75% in controls are shown.