TABLE 7.
Linkage disequilibrium between class II DRB1-DQB1 haplotypes and class I HLA-B-HLA-C haplotypes among controls
| DRB1 | DQB1 | HLA-B | HLA-C | DR-DQ frequency (%) |
B-C frequency (%) |
DR-DQ-B-C frequency (%) |
Dij | D ′ | p Value |
|---|---|---|---|---|---|---|---|---|---|
| 0101 | 0501 | 0702 | 0702 | 7.5 | 16.5 | 1.3 | 0.0001 | 0.002 | NS |
| 0101 | 0501 | 3501 | 0401 | 7.5 | 5.5 | 1.8 | 0.0134 | 0.263 | 3.2E-05 |
| 0101 | 0501 | 4001 | 0304 | 7.5 | 13.0 | 1.3 | 0.0027 | 0.042 | NS |
| 0102 | 0501 | 1402 | 0802 | 1.0 | 3.3 | 1.0 | 0.0097 | 1.000 | 8.3E-27 |
| 0301 | 02 | 0801 | 0701 | 9.5 | 9.3 | 6.8 | 0.0588 | 0.701 | 6.9E-36 |
| 0301 | 02 | 1801 | 0501 | 9.5 | 1.0 | 1.0 | 0.0091 | 1.000 | 4.5E-09 |
| 0401 | 0301 | 4001 | 0304 | 4.5 | 13.0 | 0.8 | 0.0016 | 0.042 | NS |
| 0401 | 0301 | 4402 | 0501 | 4.5 | 13.0 | 1.5 | 0.0092 | 0.233 | 0.017 |
| 0401 | 0302 | 1501 | 0304 | 3.5 | 2.3 | 1.3 | 0.0117 | 0.539 | 7.7E-17 |
| 0404 | 0302 | 4001 | 0304 | 3.3 | 13.0 | 1.5 | 0.0108 | 0.381 | 9.4E-04 |
| 0701 | 02 | 1302 | 0602 | 10.3 | 1.5 | 1.5 | 0.0135 | 1.000 | 7.1E-12 |
| 0701 | 02 | 1402 | 0802 | 10.3 | 3.3 | 0.8 | 0.0042 | 0.143 | NS |
| 0701 | 02 | 3501 | 0401 | 10.3 | 5.5 | 0.8 | 0.0019 | 0.037 | NS |
| 0701 | 02 | 4403 | 1601 | 10.3 | 3.5 | 3.0 | 0.0265 | 0.841 | 1.3E-18 |
| 0701 | 0303 | 5701 | 0602 | 4.0 | 5.0 | 3.3 | 0.0306 | 0.803 | 3.0E-42 |
| 1104 | 0301 | 1801 | 0701 | 3.3 | 1.8 | 0.8 | 0.0069 | 0.409 | 6.5E-09 |
| 1301 | 0603 | 3801 | 1203 | 5.8 | 2.5 | 1.0 | 0.0086 | 0.363 | 6.5E-06 |
| 1301 | 0603 | 4402 | 0501 | 5.8 | 13.0 | 0.8 | 0.0000 | 0.000 | NS |
| 1302 | 0604 | 0702 | 0702 | 3.3 | 16.5 | 0.8 | 0.0021 | 0.078 | NS |
| 1302 | 0604 | 4001 | 0304 | 3.3 | 13.0 | 1.5 | 0.0108 | 0.381 | 9.4E-04 |
| 1302 | 0609 | 1402 | 0802 | 1.5 | 3.3 | 0.8 | 0.0070 | 0.483 | 2.3E-10 |
| 1401 | 0503 | 0702 | 0702 | 3.3 | 16.5 | 0.8 | 0.0021 | 0.078 | NS |
| 1501 | 0602 | 0702 | 0702 | 15.8 | 16.5 | 9.3 | 0.0666 | 0.506 | 1.8E-16 |
| 1501 | 0602 | 1801 | 1203 | 15.8 | 2.0 | 1.3 | 0.0094 | 0.555 | 8.8E-04 |
| 1501 | 0602 | 4402 | 0501 | 15.8 | 13.0 | 0.8 | −0.0131 | −0.635 | NS |
See Table 1 for abbreviations.