TABLE 8.
Expected and observed T1D HLA-B allele frequencies, adjusting for linkage disequilibrium with class II DRB1-DQB1 haplotypes
| HLA B | Observed T1D frequencya (%) |
Expected T1D frequency (adjusting for LD with DR-DQ)b |
χ 2 | p Value |
|---|---|---|---|---|
| 0702 | 8.04 | 11.72 | 3.28 | NS |
| 0705 | 0.97 | 0.00 | — | — |
| 0801 | 21.82 | 19.04 | 0.88 | NS |
| 1302 | 0.71 | 1.34 | — | — |
| 1401 | 0.71 | 0.72 | — | — |
| 1402 | 1.15 | 2.79 | 3.44 | NS |
| 1501 | 12.54 | 10.48 | 0.85 | NS |
| 1801 | 8.75 | 5.09 | 4.32 | 0.038 |
| 2703 | 4.24 | 1.96 | 3.69 | NS |
| 3501 | 3.80 | 6.09 | 2.58 | NS |
| 3502 | 0.44 | 1.96 | — | — |
| 3503 | 1.15 | 0.93 | — | — |
| 3701 | 0.62 | 0.62 | — | — |
| 3801 | 1.86 | 2.37 | 0.30 | NS |
| 3901 | 1.33 | 1.13 | 0.07 | NS |
| 3906 | 3.80 | 0.62 | 9.51 | 0.002 |
| 4001 | 7.16 | 8.24 | 0.36 | NS |
| 4002 | 0.71 | 0.93 | — | — |
| 4101 | 0.88 | 0.00 | — | — |
| 4402 | 6.80 | 6.40 | 0.06 | NS |
| 4403 | 1.77 | 4.02 | 4.41 | 0.036 |
| 4901 | 1.06 | 0.72 | 0.29 | NS |
| 5001 | 1.59 | 2.04 | 0.27 | NS |
| 5101 | 2.65 | 3.55 | 0.63 | NS |
| 5301 | 0.27 | 0.93 | 1.92 | NS |
| 5501 | 0.62 | 1.34 | — | — |
| 5601 | 0.62 | 1.21 | — | — |
| 5701 | 0.44 | 1.75 | — | — |
See Table 1 for abbreviations.
a
Observed allele frequency among T1D-affected individuals.
b
Expected frequency under linkage disequilibrium (LD) estimated from affected family based controls using equation 1.