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. 2014 Jun 9;9(6):e98495. doi: 10.1371/journal.pone.0098495

Figure 2. Close-up view of the active site of the hOGG1 complexes with damaged and undamaged DNA.

Figure 2

(A) The lesion recognition complex of hOGG1 bound to DNA with the oxoG base inserted in the active site (PDB ID: 1YQR, [17]), (B) specific contacts of enzyme with the cytosine which is located opposite to oxoG base (PDB ID: 1EBM, [9]), (C) the complex of hOGG1 bound to the DNA with the G base inserted in the exo-site (PDB ID: 1YQK, [17]), (D) the complex of hOGG1 bound to the DNA, with the G base inserted in the active site (PDB ID: 3IH7, [19]). The overlays of the trapped catalytic complex hOGG1/oxoG-substrate (red, 1HU0, [16]) with either (E) the complex of hOGG1 bound to DNA with the G base inserted in the exo-site (blue, 1YQK, [17]) or (F) the complex of hOGG1 bound to DNA, with the G base inserted in the active site (green, 3IH7, [19]).