Fig. 2. T. forsythia surface glycosylation differentially regulates cytokine expression in macrophages and dendritic cells.
Inflammatory cytokine levels (A. IL-1 β, IL-6 and IL-10; B. IL12p40, IL12p70-, IL-23) were examined by ELISA in supernatants of mouse DC’s and peritoneal macrophages following challenge with either the wild-type (Tf WT) or the glycosylation deficient mutant (ED1) of T. forsythia. The data show the means ± standard deviations of triplicate determinations in one of 3 independent sets of experiments that yielded similar results; statistically significant differences between the groups are indicated by asterisks (***, p<0.001; **, p<0.01; *, p< 0.05).