Figure 4. Global Remodeling of mRNA and Protein Regulation during Batch Growth at a Constant Growth Rate.

(A) Thousands of mRNAs and proteins (FDR< 1%) either increase or decrease monotonically in abundance during the first phase of exponential growth our culture. Levels are reported on a log₂ scale with a 2 fold dynamic range. The mRNA and protein levels were measured in independent (biological replica) cultures and their correlation reflects the reproducibility of the measurements.

(B) Thousands of mRNAs and proteins (FDR< 1%) either increase or decrease monotonically in abundance during the second phase of exponential growth our culture.

(C) Metabolic pathways that show statistically significant dynamics (FDR < 1%) during the two phases of exponential growth; see Supplemental Information. The magnitude of change for each gene set is quantified as the average percent change in the level of its genes per doubling period of the cells.

See also Figure S4.