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. Author manuscript; available in PMC: 2015 Mar 26.
Published in final edited form as: Chem Rev. 2014 Jan 23;114(6):3335–3352. doi: 10.1021/cr4005555

Figure 7.

Figure 7

Asynchronous vs. synchronous stepping: do kinesins and dyneins coordinate their stepping? A. If multiple motors coordinate stepping such that they all step simultaneously (or nearly so), the cargo center of mass will move the same size as a motor step (8 nm for kinesin). B. If motors do not coordinate stepping, small movements of the cargo will occur that are fractions of a motor step (< 8 nm for kinesin) because if there are multiple kinesin, 1 stepping forward will drag the cargo forward, while the remaining kinesin will pull back, preventing the cargo from moving the full 8 nm forward.