Figure 10. Summary of complementation of S. pombe coq deletion strains by human and A. thaliana genes.

The double open circles indicate genes that complemented the S. pombe deletion mutants. The single open circles indicate genes that complemented the S. pombe deletion mutants after fusion of a mitochondrial targeting sequence. HsDLP1 is only functional in the presence of HsDPS1, so is denoted by a triangle. The “x” symbols indicate genes that failed to complement the S. pombe deletion mutants. A. thaliana does not contain a COQ7 ortholog. Closed circles indicate genes that complemented the corresponding S. cerevisiae mutants but were not tested in S. pombe.